Uppsala, Sweden: 1 PhD, 2 Postdocs at the Evolutionary Biology Centre Tisk
We seek a dedicated and talented person to join Hans Ellegren's research
group at the Evolutionary Biology Centre, Uppsala University, Sweden
(http://www.ieg.uu.se/evolutionsbiologi/ellegren-se/?languageId=1)
as bioinformatician.
 
We work with large-scale genomic approaches to general evolutionary
questions such as speciation, DNA sequence evolution and sex chromosome
evolution. Our main study system is birds and we have sequenced and
assembled the flycatcher genome in house (Ellegren et al 2012 Nature
491:756-760), and were part of the large avian phylogenomics consortium
(Jarvis et al 2014 Science 346:1320-1331). By whole-genome re-sequencing
of large population samples of different flycatcher species we gather
extensive amounts of SNP data and use these for population genomic
analyses. The bioinformatician, who will be fully integrated with the
research group, will work with genome assembly and detection of structural
variation using data from NGS-technologies that provide long (>10 kb)
reads. She/he will also be responsible for curation of flycatcher genome
sequence data and participate in research projects.
 
The position is initially for one year but can be extended. It can also
be combined with PhD studies.
 
Suitable background is a BSc or MSc in, for example, bioinformatics
or computer science. Experience from working with NGS-data in UNIX
environment is of merit, as is familiarity with relevant programming
languages (e.g. Perl, Pyton).
 
To apply for the position, please visit the Uppsala University web
site for Open Positions and log in and register your application at
http://uu.se/en/about-uu/join-us/details/?positionId=73431 
Closing date for the application is Sep 20.
 
Please feel free to contact me at 
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  with any
questions.
 
Our research group consists of some 15 scientists, including PhD students,
post-docs and bioinformaticians. The research is funded by the European
Research Council (ERC), Knut and Alice Wallenbergs Foundation and the
Swedish Research Council.
 
The venue for the position, the Evolutionary Biology Centre, is situated
in central Uppsala. The working atmosphere is international with the
great majority of PhD students and post-docs recruited from abroad. The
Centre constitutes an exciting arena for multidisciplinary research in
evolutionary biology in a broad sense, housing some 300 scientists and
graduate students. The scientific environment with numerous seminars,
journal clubs and social activities offer excellent possibilities for
contacts and collaborations. Local platforms for high-performance
computational analyses (https://www.uppmax.uu.se/uppnex), NGS, SNP
genotyping and proteomic  analyses (http://www.scilifelab.se) ensure
immediate access to state-of-the-art technology. Uppsala University
is the oldest university in Scandinavia and the city of Uppsala is a
vibrant student town with beautiful and easy accessible surroundings
conveniently situated close to Stockholm.
 
The Ellegren group is part of the Department of Evolutionary
Biology (http://www.ieg.uu.se/evolutionary-biology/), which
is a branch of the larger Department of Ecology and Genetics
(http://www.ieg.uu.se/?languageId=1). The Department of Evolutionary
Biology houses 8 independent research groups and about 25 PhD students,
25 postdocs, and several bioinformaticians. A common theme is that we
address key questions in evolutionary biology, like speciation, local
adaptation, life history evolution, genome and molecular evolution,
using genomic approaches. We have tight connections with several other
research groups in the Department of Ecology and Genetics within the
Evolutionary Biology Centre.
 
Professor Hans Ellegren
Department of Evolutionary Biology
Evolutionary Biology Centre
Uppsala University
Norbyv�gen 18D
SE-752 36 Uppsala
Sweden
 
Email: 
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LAB WEB PAGE:
http://www.ieg.uu.se/evolutionsbiologi/ellegren-se/?languageId=1

************************

Two post-doctoral positions in population genomics
Two two-year post-doctoral positions are available in the Ellegren

lab at the Evolutionary Biology Centre, Uppsala University, Sweden
(http://www.ieg.uu.se/evolutionsbiologi/ellegren-se/?languageId=3D1). Two
positions are broadly defined as population genomics (presented below)
and one as molecular evolution, although there is some extent of overlap
both in terms of concepts and data used among the positions.
 
1. Population genomics
 
We use flycatchers of the genus Ficedula to study evolutionary
processes related to the evolution of heterogeneous genomic landscapes
of species differentiation (e.g. Ellegren et al 2012 Nature
491:756-760). There is increasing evidence that genomic regions with
elevated differentiation ('differentiation islands') can evolve by
processes unrelated to speciation. For example, the concept of linked
selection, which is particularly pronounced in low-recombining regions,
will locally reduce the effective population size and thereby enhance
genetic drift of segregating variants. Pursuing these studies using
haplotype-based statistics and NGS-data from sequencing platforms
generating long reads is one possible direction of research for the
post-doc. Other directions include, for example, demographic analyses
and studies of the recombination landscape. The specific questions to
be addressed will be decided in dialogue with the successful candidate
and will depend on her/his interests and background.
Recent publications from the group relating to the project include
Nadachowska-Brzyska et al 2015 Current Biology 25:1375-1380; Nater et
al 2015 Systematic Biology, in press; Smeds et al. 2015 Nature
Communications 6:7330; Suh et al 2015 PLoS Biology 13:1002224.
 
2. Population genomics
The wolf was once widespread in Scandinavia, as well as in other parts
of Europe, but long-term persecution led to its extinction by the
1960s. Two animals founded a new population in Sweden in the 1970s and
a limited number of immigrants have subsequently become integrated with
the population and it has grown to several hundreds of individuals. The
population is highly inbred (inbreeding coefficient of newborns is
currently 0.25 on average) and there are signs of inbreeding
depression. We are now conducting whole-genome re-sequecning of 100
animals sampled from throughout the time period since the new
population was founded. The post-doc will be responsible for analysing
these data with the aims of investigating the rate of allelic loss, the
extent and distribution of genomic regions identical-by-descent, the
genomic contribution of each founder to the extant population, and to
compare genetic relationships derived from the pedigree and genome
sequence data. Several other research questions can apply as well. The
project is a collaboration with Grimso Wildlife Research Station of the
Swedish University of Agricultural Sciences.
 
Suitable background to these position is a PhD geared toward
evolutionary biology, population genetics, or bioinformatics.
Experience from bioinformatic analyses of next-generation sequencing
data is of merit. Depending on the direction of research to be taken,
experience of demographic modeling, molecular evolutionary analyses or
conservation biology could also be of merit.
 
Start date is flexible, ideally before January 1, 2016. The positions
can be extended for up to two more years.
For full consideration, please send application materials by September
18, 2015. Interested candidates should submit the following
to 
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- a cover letter stating research interests,
- CV, including publication record
- a short (1-2 page) description of research accomplishments,
- email addresses and phone numbers of three references
Please feel free to contact me at the above email address with
questions.
 
The venue for the positions, the Evolutionary Biology Centre, is situated
in central Uppsala. The working atmosphere is international with the
great majority of PhD students and post-docs recruited from abroad. The
Centre constitutes an exciting arena for multidisciplinary research in
evolutionary biology in a broad sense, housing some 300 scientists and
graduate students. The scientific environment with numerous seminars,
journal clubs and social activities offer excellent possibilities for
contacts and collaborations. Local platforms for high-performance
computational analyses (https://www.uppmax.uu.se/uppnex), NGS, SNP
genotyping and proteomic analyses (http://www.scilifelab.se) ensure
immediate access to state-of-the-art technology. Uppsala University
is the oldest university in Scandinavia and the city of Uppsala is a
vibrant student town with beautiful and easy accessible surroundings
conveniently situated close to Stockholm.
 
The Ellegren group is part of the Department of Evolutionary
Biology (http://www.ieg.uu.se/evolutionary-biology/), which
is a branch of the larger Department of Ecology and Genetics
(http://www.ieg.uu.se/?languageId=3D1). The Department of Evolutionary
Biology houses 8 independent research groups and about 25 PhD students,
25 postdocs, and several bioinformaticians. A common theme is that we
address key questions in evolutionary biology, like speciation, local
adaptation, life history evolution, genome and molecular evolution,
using genomic approaches. We have tight connections with several other
research groups in the Department of Ecology and Genetics within the
Evolutionary Biology Centre.
 
Professor Hans Ellegren
Department of Evolutionary Biology
Evolutionary Biology Centre
Uppsala University
Norbyv=C3=A4gen 18D
SE-752 36 Uppsala
Sweden
Email: 
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LAB WEB
PAGE: http://www.ieg.uu.se/evolutionsbiologi/ellegren-se/?languageId=3D1