The genetic mechanisms of adaptation:

Post-doc position in the Division of Computational Genetics, Department

of Clinical Sciences, SLU, Uppsala, Sweden 

A Post-doc position is available in a project where we study the

genetic mechanisms of adaptation. In the project we do in-depth

analyses of data from mainly two model systems: i) A long-term

selection experiment in domestic chicken and ii) Large collections of

natural Arabidopsis thaliana accessions. 

The focus in the project is to

develop and use new quantitative-, population-, and evolutionary

genetics approaches to analyze already available data. Depending on the

background, competence and interests of the applicant, the project can

be focused either on the development of new genetics theory,

statistical methods, computational algorithms and bioinformatics tools,

analyses of empirical data using methods developed by others working on

the project, or a combination of the two.

Examples of earlier work in this project include:

Opinion articles

1. Carlborg, Ö. and Haley, C. Epistasis: too often neglected in complex

   traits studies? Nature Reviews Genetics 2004 5: 618-625.

2. Le Rouzic, A. and Carlborg, Ö. Evolutionary potential of hidden

   genetic variation. Trends in Ecology and Evolution 2008 23:33-37.

3. Nelson, R.M., Pettersson, M.E., Carlborg, Ö. A century after Fisher:

   time for a new paradigm in quantitative genetics. Trends Genet. 2013

   29:669-76.

Original publications

1. Carlborg, Ö., Jacobsson, L., Åhgren, P., Siegel, P., Andersson, L.

   Epistasis and the release of genetic variation during long-term

   selection. Nature Genetics 2006 38:418-20.

2. Alvarez-Castro, J. and Carlborg, Ö. A general model for functional

   and statistical epistasis and its application in QTL analysis.

   Genetics 2007 176: 1151-1167

3. Alvarez-Castro, J., le Rouzic, A. and Carlborg, Ö. How to perform

   meaningful estimates of genetic effects. PLOS Genetics 2008 May 2;

   4(5):e1000062

4. Le Rouzic, A., Alvarez-Castro, J. and Carlborg, Ö. Dissection of the

   genetic architecture of body weight in chicken reveals the impact of

   epistasis on domestication traits. Genetics 2008 179:1591-1599.

5. Johansson, A.M., Pettersson, M.E., Siegel, P.B. and Carlborg, Ö. Genome-

   wide effects of long-term divergent selection. PLoS Genet. 2010

   6(11):e1001188.

6. Pettersson, M.E., Besnier, F., Siegel, P. and Carlborg, Ö. 2011.

   Replication and explorations of high-order epistasis using a large

   Advanced Intercross Line pedigree. PLOS Genetics, Jul;7(7):e1002180.

7. Shen, X., Pettersson, M., RĂśnnegĂĽrd, L. and Carlborg, Ö.

   Inheritance beyond plain heritability: variance-controlling genes

   in Arabidopsis thaliana. PLoS Genetics 2012 8(8):e1002839. Epub

   2012 Aug 2.

8. Nelson, R.M., Pettersson, M.P., LI, X., Carlborg, Ö. 2013. Variance

   heterogeneity in Saccharomyces cerevisiae expression data: trans-

   regulation and epistasis. PLoS One. 2013 8:e79507.

9. Shen, X., De Jonge, J., Forsberg, S., Pettersson, M., Sheng, Z.,

   Hennig, L., and Carlborg, Ö. Natural CMT2 variation is associated

   with genome-wide methylation changes and temperature seasonality.

   PLoS Genet. 2014 10(12): e1004842

10. Lachowiec, J., Shen, X., Queitsch, C. and Carlborg, Ö. Highly

    epistatic genetic architecture of root length in Arabidopsis

    thaliana. BIORXIV/2014/008789

To be suitable for the post, we believe that you have a thorough

theoretical background in quantitative-, population- or evolutionary

genetics and an interest in using this knowledge to improve our

understanding of the genetic mechanisms contributing to adaptation via

analyses of empirical data. You have probably also have experience in

performing quantitative-, population- or evolutionary genetics analyses

in empirical data. As we use R as a common platform for all our work,

previous experience in R-programming is an advantage.

The post is available immediately and we are now looking for candidates

are available to start the post by April 1, 2015 at the latest. Forms

for funding or employment Employment as Post-doctoral researcher student

for 1 year with possibility of extension 1+2 years.

If you have questions about the post, us or our work, please contact

Örjan Carlborg (
 Tato emailová adresa je chráněna před spamboty, abyste ji viděli, povolte JavaScript
 )

We are looking forward to hearing from you!

 Tato emailová adresa je chráněna před spamboty, abyste ji viděli, povolte JavaScript