Katedra zoologie

Přírodovědecká fakulta Jihočeské univerzity

Úvodní stránka
Uppsala, Sweden: Postdoc, genetic mechanisms of adaptation PDF Tisk Email
The genetic mechanisms of adaptation:
Post-doc position in the Division of Computational Genetics, Department
of Clinical Sciences, SLU, Uppsala, Sweden 
A Post-doc position is available in a project where we study the
genetic mechanisms of adaptation. In the project we do in-depth
analyses of data from mainly two model systems: i) A long-term
selection experiment in domestic chicken and ii) Large collections of
natural Arabidopsis thaliana accessions. 
The focus in the project is to
develop and use new quantitative-, population-, and evolutionary
genetics approaches to analyze already available data. Depending on the
background, competence and interests of the applicant, the project can
be focused either on the development of new genetics theory,
statistical methods, computational algorithms and bioinformatics tools,
analyses of empirical data using methods developed by others working on
the project, or a combination of the two.
Examples of earlier work in this project include:
Opinion articles
1. Carlborg, Ö. and Haley, C. Epistasis: too often neglected in complex
   traits studies? Nature Reviews Genetics 2004 5: 618-625.
2. Le Rouzic, A. and Carlborg, Ö. Evolutionary potential of hidden
   genetic variation. Trends in Ecology and Evolution 2008 23:33-37.
3. Nelson, R.M., Pettersson, M.E., Carlborg, Ö. A century after Fisher:
   time for a new paradigm in quantitative genetics. Trends Genet. 2013
Original publications
1. Carlborg, Ö., Jacobsson, L., Åhgren, P., Siegel, P., Andersson, L.
   Epistasis and the release of genetic variation during long-term
   selection. Nature Genetics 2006 38:418-20.
2. Alvarez-Castro, J. and Carlborg, Ö. A general model for functional
   and statistical epistasis and its application in QTL analysis.
   Genetics 2007 176: 1151-1167
3. Alvarez-Castro, J., le Rouzic, A. and Carlborg, Ö. How to perform
   meaningful estimates of genetic effects. PLOS Genetics 2008 May 2;
4. Le Rouzic, A., Alvarez-Castro, J. and Carlborg, Ö. Dissection of the
   genetic architecture of body weight in chicken reveals the impact of
   epistasis on domestication traits. Genetics 2008 179:1591-1599.
5. Johansson, A.M., Pettersson, M.E., Siegel, P.B. and Carlborg, Ö. Genome-
   wide effects of long-term divergent selection. PLoS Genet. 2010
6. Pettersson, M.E., Besnier, F., Siegel, P. and Carlborg, Ö. 2011.
   Replication and explorations of high-order epistasis using a large
   Advanced Intercross Line pedigree. PLOS Genetics, Jul;7(7):e1002180.
7. Shen, X., Pettersson, M., RĂśnnegĂĽrd, L. and Carlborg, Ö.
   Inheritance beyond plain heritability: variance-controlling genes
   in Arabidopsis thaliana. PLoS Genetics 2012 8(8):e1002839. Epub
   2012 Aug 2.
8. Nelson, R.M., Pettersson, M.P., LI, X., Carlborg, Ö. 2013. Variance
   heterogeneity in Saccharomyces cerevisiae expression data: trans-
   regulation and epistasis. PLoS One. 2013 8:e79507.
9. Shen, X., De Jonge, J., Forsberg, S., Pettersson, M., Sheng, Z.,
   Hennig, L., and Carlborg, Ö. Natural CMT2 variation is associated
   with genome-wide methylation changes and temperature seasonality.
   PLoS Genet. 2014 10(12): e1004842
10. Lachowiec, J., Shen, X., Queitsch, C. and Carlborg, Ö. Highly
    epistatic genetic architecture of root length in Arabidopsis
    thaliana. BIORXIV/2014/008789
To be suitable for the post, we believe that you have a thorough
theoretical background in quantitative-, population- or evolutionary
genetics and an interest in using this knowledge to improve our
understanding of the genetic mechanisms contributing to adaptation via
analyses of empirical data. You have probably also have experience in
performing quantitative-, population- or evolutionary genetics analyses
in empirical data. As we use R as a common platform for all our work,
previous experience in R-programming is an advantage.
The post is available immediately and we are now looking for candidates
are available to start the post by April 1, 2015 at the latest. Forms
for funding or employment Employment as Post-doctoral researcher student
for 1 year with possibility of extension 1+2 years.
If you have questions about the post, us or our work, please contact
Örjan Carlborg (
 Tato emailová adresa je chráněna před spamboty, abyste ji viděli, povolte JavaScript
We are looking forward to hearing from you!

 Tato emailová adresa je chráněna před spamboty, abyste ji viděli, povolte JavaScript
Joomla 1.5 Templates by Joomlashack