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Evolutionary ecology of life-long telomere dynamics in a wild mammal population
at the University of Edinburgh
A postdoctoral position is available for 2.5 years in Dan Nusseyâs
group at the University of Edinburgh investigating the evolutionary
ecology and genetics of telomere dynamics in a wild Soay sheep population.
Telomeres are repetitive DNA sequences that cap the ends of vertebrate
chromosomes. They play at pivotal role in the maintenance of genomic
integrity and regulation of senescence at a cellular level, and there is
growing interest across disciplines in the utility of telomere length
measured in blood cells as a biomarker of ageing and health.
The project, funded by BBSRC, is based on the long-term study of Soay
sheep on St Kilda and will utilise a large freezer bank of blood samples
(>8000) collected since 1990 to measure telomere dynamics from birth to
death for thousands of individuals, alongside other genetic, phenotypic,
life history and fitness data collected as part of the study.
The post-doc will work closely with an established and experienced team
in the laboratory to generate leukocyte telomere length (LTL)
measurements from these blood samples. Their principal responsibility
will be to analyse the data produced to address key questions for both
evolutionary ecologists and telomere biologists, including: (1) To what
degree early-life LTL versus life-long changes in LTL drive
population-level variation in LTL, (2) How do early-life environmental
conditions and genes contribute to LTL variation, (3) How does natural
selection act on LTL across the entire lifespan.
Contact Dan Nussey
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see http://nussey.bio.ed.ac.uk/ for more information
Or search for job reference 033045 at https://www.vacancies.ed.ac.uk for
application details.
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Dan Nussey
BBSRC David Phillips fellow
& Reader in Evolutionary Ecology,
Institute of Evolutionary Biology,
University of Edinburgh,
The Kings Buildings,
West Mains Road, Edinburgh EH9 3JT
Tel: +44 (0)131 6505494
Email:
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Website:http://nussey.bio.ed.ac.uk/
Dan Nussey <
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